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Publication : Death receptors DR6 and TROY regulate brain vascular development.

First Author  Tam SJ Year  2012
Journal  Dev Cell Volume  22
Issue  2 Pages  403-17
PubMed ID  22340501 Mgi Jnum  J:181470
Mgi Id  MGI:5311494 Doi  10.1016/j.devcel.2011.11.018
Citation  Tam SJ, et al. (2012) Death Receptors DR6 and TROY Regulate Brain Vascular Development. Dev Cell 22(2):403-17
abstractText  Signaling events that regulate central nervous system (CNS) angiogenesis and blood-brain barrier (BBB) formation are only beginning to be elucidated. By evaluating the gene expression profile of mouse vasculature, we identified DR6/TNFRSF21 and TROY/TNFRSF19 as regulators of CNS-specific angiogenesis in both zebrafish and mice. Furthermore, these two death receptors interact both genetically and physically and are required for vascular endothelial growth factor (VEGF)-mediated JNK activation and subsequent human brain endothelial sprouting in vitro. Increasing beta-catenin levels in brain endothelium upregulate DR6 and TROY, indicating that these death receptors are downstream target genes of Wnt/beta-catenin signaling, which has been shown to be required for BBB development. These findings define a role for death receptors DR6 and TROY in CNS-specific vascular development.
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