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Publication : PDK1: At the crossroad of cancer signaling pathways.

First Author  Gagliardi PA Year  2018
Journal  Semin Cancer Biol Volume  48
Pages  27-35 PubMed ID  28473254
Mgi Jnum  J:261093 Mgi Id  MGI:6153436
Doi  10.1016/j.semcancer.2017.04.014 Citation  Gagliardi PA, et al. (2018) PDK1: At the crossroad of cancer signaling pathways. Semin Cancer Biol 48:27-35
abstractText  Rational target therapy of cancer would benefit from the identification of new targets that can be easily inhibited by small molecules. An increasing amount of evidence hints at 3-phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1) as an intriguing and underexplored target for cancer therapy. Several reports show that PDK1 expression is dysregulated in multiple cancer types. Furthermore PDK1 is implicated in signaling pathways frequently altered in cancer, such as PI3K/Akt, Ras/MAPK and Myc. PDK1 targeting has been proven to be effective in experimental models harboring alterations of these pathways. In this paper we review PDK1 main biochemical mechanisms, its alterations in cancer and interactions with relevant cancer pathways. A potential role of PDK1 in tumor microenvironment is also discussed.
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