| First Author | Mijimolle N | Year | 2005 |
| Journal | Cancer Cell | Volume | 7 |
| Issue | 4 | Pages | 313-24 |
| PubMed ID | 15837621 | Mgi Jnum | J:98944 |
| Mgi Id | MGI:3580759 | Doi | 10.1016/j.ccr.2005.03.004 |
| Citation | Mijimolle N, et al. (2005) Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell 7(4):313-24 |
| abstractText | Protein farnesyltransferase (FTase) is an enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif. Farnesylation allows substrates to interact with membranes and protein targets. Using gene-targeted mice, we report that FTase is essential for embryonic development, but dispensable for adult homeostasis. Six-month-old FTase-deficient mice display delayed wound healing and maturation defects in erythroid cells. Embryonic fibroblasts lacking FTase have a flat morphology and reduced motility and proliferation rates. Ablation of FTase in two ras oncogene-dependent tumor models has no significant consequences for tumor initiation. However, elimination of FTase during tumor progression had a limited but significant inhibitory effect. These results should help to better understand the role of protein farnesylation in normal tissues and in tumor development. |
