| Primary Identifier | IPR046328 | Type | Family |
| Short Name | ETS_fam |
| description | This entry represents ETS family of transcription factors, including ETS translocation variant 1-5 (ETV1-5) and related proteins from animals. Most members of this protein family contain an ETS (erythroblast transformation specific) domain and belong to the winged helix DNA-binding domain superfamily.ETV1-5 are overexpressed in multiple cancers [, , ]. ETV1 is critical for fast conduction physiology in the heart []. ETV3 is a transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation []. ETV4 is a transcriptional activator that may play a role in keratinocyte differentiation [, ]. |
