| Primary Identifier | IPR029836 | Type | Family |
| Short Name | ATF2 |
| description | Activating transcription factor or cAMP-dependent transcription factor ATF-2, also known as CRE-BP1, regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. ATF-2 needs to be phosphorylated by Jun N-terminal kinase (JNK), p38 (MAPK14), or extracellular-signal-regulated kinase 1 (ERK1) in order to be transcriptionally active. Activated ATF-2 then form dimers with proteins, such as members of the AP-1 family, and regulates gene transcription []. It has been implicated in several pathological conditions, including neurological diseases and cancer [, ]. |
