Primary Identifier | IPR004580 | Type | Family |
Short Name | Rad18_fungi |
description | During DNA replication, lesion bypass is an important cellular response to unrepaired damage in the genome. In the yeastSaccharomyces cerevisiae (Baker's yeast), Rad6 and Rad18 are required for both the error-free and error-prone lesion bypass mechanisms. The Rad18 gene encodes a RING-finger protein with single-stranded DNA binding activity that interacts with theubiquitin-conjugating enzyme Rad6. This entry represents the Rad8 from fungi. |