| Primary Identifier | IPR035435 | Type | Family |
| Short Name | DPH1/DPH2_euk_archaea |
| description | This entry includes diphthamide synthesis DPH1 from eukaryotes and archaea and DPH2 from archaea.Archaeal and eukaryotic translation elongation factor 2 (EF-2) contain a unique posttranslationally modified histidine residue called diphthamide, which become the target for ADP-ribosylation by diphtheria toxin []. DPH1 catalyzes the first step of diphthamide biosynthesis and is required for the modification of EF-2 []. The human DPH1 is also known as OVCA1 (for ovarian cancer gene 1), a tumour suppressor gene that plays a crucial role in the regulation of cell proliferation, embryonic development, and tumorigenesis []. |
