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Protein Domain : Voltage-dependent calcium channel, T-type, alpha-1I subunit

Primary Identifier  IPR030162 Type  Family
Short Name  CACNA1I
description  This entry represents the T-type voltage-dependent calcium channel alpha-1I subtype, also known as Cav3.3. Sperm-specific CatSper1 and CatSper2 proteins can associate with and modulate the function of this channel, which might be important in the regulation of sperm motility []. It may also play a role in regulating GABAergic neurons [].Voltage-dependent calcium channels (VDCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. T-type VDCC belongs to low-voltage-activated (LVA) Ca2+ channels, whereas others belong to high-voltage-activated (HVA) Ca2+ channels.VDCCs consist of subunits. The alpha-1 subunit constitute the pore region which determines the fundamental channel properties []. Three types of alpha-1 subunit have been identified in T-type VDCCs molecules: alpha-1G [], alpha-1H [], and alpha-1I []. T-currents generated by the alpha-1I subunit display slow kinetics that differ markedly from the alpha-1G and alpha-1H currents [, , ].

0 Child Features

0 Contains

0 Found In

1 Parent Features

5 Protein Domain Regions