| Primary Identifier | IPR009828 | Type | Domain |
| Short Name | CYRIA/CYRIB_Rac1-bd |
| description | This domain has been annotated as Rac1-binding domain [, ]. It can be found in human CYRIA/CYRIB and at the N terminus of CYFIP1/2 []. CYFIP proteins are known RAC1 effectors that stimulate actin polymerization []. CYRIA/B are also localised to early macropinosomes and act to modulate their formation by regulating Rac1 signalling []. In mice, CYRIB (also known as CYRI or FAM49B) negatively regulates RAC1-driven cytoskeletal remodelling and plays a role in restricting infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes []. |
