| Primary Identifier | IPR010832 | Type | Family |
| Short Name | ProSAAS |
| description | Prohormone convertases (PCs) 1 and 2 are a family of eukaryotic subtilisins thought to mediate the proteolytic cleavage of many peptide precursors [].This family represents proSAAS, which belongs to MEROPS inhibitor family I49. It is a neuroendocrine secretory protein which is a potent endogenous PC1 inhibitor [, ]. ProSAAS consists of an N-terminal domain and a C-terminal domain separated by a furin cleavage site. The inhibitory region of proSAAS is located in the C-terminal domain and includes the LLRVKR hexapeptide sequence [, , ]. Furthermore, ProSAAS has been shown to function as an amyloid anti-aggregant chaperon in Alzheimer's disease []. ProSAAS-derived peptides are involved in several physiologically important processes [, , ]. |
