| Primary Identifier | IPR044202 | Type | Family |
| Short Name | LETM1/MDM38-like |
| description | This family represents a group of LETM1-like mitochondrial inner membrane proteins, including LETM1/LETM2 from mammals and YLH47/MDM38 from yeastsLETM1 is a proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion []. LETM2 is preferentially expressed in testis and sperm. In humans, deletion of LETM1 causes Wolf-Hirschhorn syndrome []. MDM38 is involved in potassium homeostasis []and, with MBA1, it plays a role in ribosomal translation and protein insertion into the inner membrane []. |
