| Primary Identifier | IPR034875 | Type | Family |
| Short Name | TAF15 |
| description | TATA binding associated factor 15 (TAF15) belongs to the TET (TAF15/EWS/TLS) or FET (FUS/EWS/TLS) protein family []. It is a nuclear RNA-binding protein that is associated with a distinct population of TFIID and RNA polymerase II complexes []. It also interacts with the U1 snRNP component of the spliceosome []. TAF15 can be methylated by protein arginine N-methyltransferase 1 (PRMT1), and this modification is a crucial event determining its proper localization and gene regulatory function []. It has been linked to familial amyotrophic lateral sclerosis (FALS) [].TAF15/EWS/TLS family members include human FUS (Fused in liposarcoma), EWS (Ewing Sarcoma) and TAF15 (TATA binding associated factor 15), and the Drosophila orthologue Cabeza. They are RNA binding proteins that contain a transcriptional-activation domain (EAD), 3 glycine-arginine (RGG) rich regions, an RNA-binding domain (RBD), and a zinc finger domain [, ]. They are involved in transcription and alternative splicing. They are subjected to different environmental signals that induce post-translational modifications in their RBD and in the RGG domains, thus modulating their activity []. TAF15/EWS/TLS play important roles in oncogenesis and neuronal disease []. |
