| Primary Identifier | IPR039789 | Type | Family |
| Short Name | CYRI |
| description | This entry includes CYRI (CYFIP-related Rac interactor) from Dictyostelium and its homologues, CYRIA/CYRIB, from animals. CYRI binds activated Rac1 via a domain of unknown function (DUF1394). It plays important roles in cell migration, chemotaxis and pathogen entry into cells. It controls actin dynamics through Rac1, the Scar/WAVE Complex and the Arp2/3 Complex [, ]. In mice, CYRIB (also known as CYRI or FAM49B) negatively regulates RAC1-driven cytoskeletal remodelling and plays a role in restricting infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes []. |
