| Primary Identifier | IPR037596 | Type | Family |
| Short Name | Sec13 |
| description | Sec13 is a subunit of the Nup84 (Nup107-160 complex in higher eukaryotes) nuclear pore subcomplex []and the the SEA complex (GATOR1 complex in higher eukaryotes) [, , ]. Besides Nup84 and SEA complexes, Sec13 is also part of the COPII vesicle coat required for ER-to-Golgi transport [, ].The Nup107-160 complex, which is the major structural subcomplex of the nuclear pore complex (NPC), functions in the regulation of mRNA export as well as in the assembly and distribution of NPCs within the nuclear envelope, and may also have functions independent of nucleocytoplasmic transport [].In budding yeasts, the SEA complex associates with the vacuole and is involved in intracellular trafficking, amino acid biogenesis, and response to nitrogen starvation []. In Drosophila, GATOR1 complex inhibits TORC1 activity in response to amino acid limitation and contributes to multiple aspects of the development []. Both Sec13 and Seh1 are positive regulators of TORC1 signalling []. |
