| Primary Identifier | IPR011159 | Type | Family |
| Short Name | PPPtase_PPZ/Ppq1 |
| description | This group represents the yeast phosphoprotein phosphatase, Ppz-type. Ppz proteins function in the regulation of K+ transport. Ppz proteins and the Hal3p inhibitory subunit of Ppz1 are important determinants of salt tolerance, cell wall integrity and cell cycle progression, each of which is dependent upon the Trk K+ transporters [, ]. The decreased Ppz activity found in Ppz mutants results in the activation of Trk and the subsequent plasma membrane depolarisation (reducing uptake of toxic cations), increased intracellular K+ and turgor (compromising cell integrity), and increased intracellular pH (augmenting the expression of pH-regulated genes and facilitating alpha-factor recovery). Ppz1 orthologues are found only in fungi [].Ppq1 yeast phosphatase consists of two distinct domains: the C-terminal phosphatase domain is approximately 60% identical to either PP1 or the carboxy-terminal domains of PPZ1 and PPZ2, while the N-terminal region is rich in serine and asparagine. Ppq1 seems to be involved in the regulation of protein synthesis []and functions as a negative regulator of the mating MAPK pathway []. |
