Primary Identifier | IPR037939 | Type | Family |
Short Name | CRADD |
description | CRADD (Caspase and RIP adaptor, also known as RAIDD) is an adaptor protein that together with the p53-inducible protein PIDD and caspase-2, forms the PIDDosome complex, which is required for caspase-2 activation and plays a role in mediating stress-induced apoptosis []. It contains an N-terminal CARD, which interacts with the caspase-2 CARD, and a C-terminal Death domain (DD), which interacts with the DD of PIDD []. |