| First Author | Pascutti MF | Year | 2019 |
| Journal | Eur J Immunol | Volume | 49 |
| Issue | 6 | Pages | 853-872 |
| PubMed ID | 30891737 | Mgi Jnum | J:277138 |
| Mgi Id | MGI:6317138 | Doi | 10.1002/eji.201848003 |
| Citation | Pascutti MF, et al. (2019) Peripheral and systemic antigens elicit an expandable pool of resident memory CD8(+) T cells in the bone marrow. Eur J Immunol 49(6):853-872 |
| abstractText | BM has been put forward as a major reservoir for memory CD8(+) T cells. In order to fulfill that function, BM should "store" memory CD8(+) T cells, which in biological terms would require these "stored" memory cells to be in disequilibrium with the circulatory pool. This issue is a matter of ongoing debate. Here, we unequivocally demonstrate that murine and human BM harbors a population of tissue-resident memory CD8(+) T (TRM ) cells. These cells develop against various pathogens, independently of BM infection or local antigen recognition. BM CD8(+) TRM cells share a transcriptional program with resident lymphoid cells in other tissues; they are polyfunctional cytokine producers and dependent on IL-15, Blimp-1, and Hobit. CD8(+) TRM cells reside in the BM parenchyma, but are in close contact with the circulation. Moreover, this pool of resident T cells is not size-restricted and expands upon peripheral antigenic re-challenge. This works extends the role of the BM in the maintenance of CD8(+) T cell memory to include the preservation of an expandable reservoir of functional, non-recirculating memory CD8(+) T cells, which develop in response to a large variety of peripheral antigens. |
