| First Author | Fujikawa T | Year | 2016 |
| Journal | Elife | Volume | 5 |
| PubMed ID | 27874828 | Mgi Jnum | J:239175 |
| Mgi Id | MGI:5825399 | Doi | 10.7554/eLife.18206 |
| Citation | Fujikawa T, et al. (2016) SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise. Elife 5:e18206 |
| abstractText | Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the exercise remains less clear. Here, using genetically engineered mice we assessed the requirement of steroidogenic factor-1 (SF-1) expression in neurons of the ventromedial hypothalamic nucleus (VMH) in mediating the beneficial effects of exercise on metabolism. We found that VMH-specific deletion of SF-1 blunts (a) the reductions in fat mass, (b) improvements in glycemia, and (c) increases in energy expenditure that are associated with exercise training. Unexpectedly, we found that SF-1 deletion in the VMH attenuates metabolic responses of skeletal muscle to exercise, including induction of PGC-1alpha expression. Collectively, this evidence suggests that SF-1 expression in VMH neurons is required for the beneficial effects of exercise on metabolism. |
