| First Author | Koike T | Year | 2015 |
| Journal | Sci Rep | Volume | 5 |
| Pages | 8994 | PubMed ID | 25759206 |
| Mgi Jnum | J:253793 | Mgi Id | MGI:6102399 |
| Doi | 10.1038/srep08994 | Citation | Koike T, et al. (2015) Chondroitin sulfate-E mediates estrogen-induced osteoanabolism. Sci Rep 5:8994 |
| abstractText | Osteoporosis is an age-related disorder of bone remodeling in which bone resorption outstrips bone matrix deposition. Although anticatabolic agents are frequently used as first-line therapies for osteoporosis, alternative anabolic strategies that can enhance anabolic, osteogenic potential are actively sought. Sex steroid hormones, particularly estrogens, are bidirectional regulators for bone homeostasis; therefore, estrogen-mediated events are important potential targets for such anabolic therapies. Here, we show that estrogen-induced, osteoanabolic effects were mediated via enhanced production of chondroitin sulfate-E (CS-E), which could act as an osteogenic stimulant in our cell-based system. Conversely, estrogen deficiency caused reduced expression of CS-E-synthesizing enzymes, including GalNAc4S-6ST, and led to decreased CS-E production in cultures of bone marrow cells derived from ovariectomized mice. Moreover, Galnac4s6st-deficient mice had abnormally low bone mass that resulted from impaired osteoblast differentiation. These results indicated that strategies aimed at boosting CS-E biosynthesis are promising alternative therapies for osteoporosis. |
