| First Author | Cao L | Year | 2021 |
| Journal | J Invest Dermatol | Volume | 141 |
| Issue | 10 | Pages | 2499-2508.e3 |
| PubMed ID | 33812858 | Mgi Jnum | J:321404 |
| Mgi Id | MGI:6789630 | Doi | 10.1016/j.jid.2021.03.015 |
| Citation | Cao L, et al. (2021) Mechanisms of Broad-Band UVB IrradiationInduced Itch in Mice. J Invest Dermatol 141(10):2499-2508.e3 |
| abstractText | Although sunburn can produce severe uncontrollable itching, the underlying mechanisms of UV irradiationinduced itch are poorly understood because of a lack of experimental animal models of sunburn itch. In this study, we established a sunburn-related mouse model and found that broad-band UVB irradiation elicited scratching but not wiping behavior in mice. Using a combination of live-cell calcium ion imaging and quantitative RT-PCR on dorsal root ganglion neurons, H&E staining, immunofluorescence staining of skin preparations, and behavioral testing, in combination with genetic and pharmacological approaches, we showed that TRPV1-positive dorsal root ganglion neurons but not mast cells are involved in broad-band UVB irradiationinduced itch. Moreover, both genetic and pharmacological inhibition of TRPV1 function significantly alleviated the broad-band UVB irradiationinduced itch response. Collectively, our results suggest that broad-band UVB irradiation evokes itch sensation in mice by promoting TRPV1 channel function in dorsal root ganglion neurons and provide potential therapeutic targets for sunburn-related itch. |
