First Author | Choi HS | Year | 2020 |
Journal | Cell Rep | Volume | 30 |
Issue | 9 | Pages | 2989-3003.e6 |
PubMed ID | 32130902 | Mgi Jnum | J:288354 |
Mgi Id | MGI:6416658 | Doi | 10.1016/j.celrep.2020.02.040 |
Citation | Choi HS, et al. (2020) Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis. Cell Rep 30(9):2989-3003.e6 |
abstractText | We find that cardiac group 2 innate lymphoid cells (ILC2s) are essential for the development of IL-33-induced eosinophilic pericarditis. We show a pathogenic role for ILC2s in cardiac inflammation, in which ILC2s activated by IL-33 drive the development of eosinophilic pericarditis in collaboration with cardiac fibroblasts. ILCs, not T and B cells, are required for the development of pericarditis. ILC2s transferred to the heart of Rag2(-/-)Il2rg(-/-) mice restore their susceptibility to eosinophil infiltration. Moreover, ILC2s direct cardiac fibroblasts to produce eotaxin-1. We also find that eosinophils reside in the mediastinal cavity and that eosinophils transferred to the mediastinal cavity of eosinophil-deficient DeltadblGATA1 mice following IL-33 treatment migrate to the heart. Thus, the serous cavities may serve as a reservoir of cardiac-infiltrating eosinophils. In humans, patients with pericarditis show higher amounts of ILCs in pericardial fluid than do healthy controls and patients with other cardiac diseases. We demonstrate that ILCs play a critical role in pericarditis. |