| First Author | Charbonnier LM | Year | 2015 |
| Journal | Nat Immunol | Volume | 16 |
| Issue | 11 | Pages | 1162-73 |
| PubMed ID | 26437242 | Mgi Jnum | J:260120 |
| Mgi Id | MGI:6141068 | Doi | 10.1038/ni.3288 |
| Citation | Charbonnier LM, et al. (2015) Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling. Nat Immunol 16(11):1162-73 |
| abstractText | Receptors of the Notch family direct the differentiation of helper T cell subsets, but their influence on regulatory T cell (T(reg) cell) responses is obscure. We found here that lineage-specific deletion of components of the Notch pathway enhanced T(reg) cell-mediated suppression of type 1 helper T cell (T(H)1 cell) responses and protected against their T(H)1 skewing and apoptosis. In contrast, expression in T(reg) cells of a gain-of-function transgene encoding the Notch1 intracellular domain resulted in lymphoproliferation, exacerbated T(H)1 responses and autoimmunity. Cell-intrinsic canonical Notch signaling impaired T(reg) cell fitness and promoted the acquisition by T(reg) cells of a T(H)1 cell-like phenotype, whereas non-canonical Notch signaling dependent on the adaptor Rictor activated the kinase AKT-transcription factor Foxo1 axis and impaired the epigenetic stability of Foxp3. Our findings establish a critical role for Notch signaling in controlling peripheral T(reg) cell function. |
