| First Author | Johnson DR | Year | 1975 |
| Journal | J Reprod Fertil | Volume | 42 |
| Issue | 1 | Pages | 51-8 |
| PubMed ID | 162962 | Mgi Jnum | J:5508 |
| Mgi Id | MGI:53986 | Doi | 10.1530/jrf.0.0420051 |
| Citation | Johnson DR, et al. (1975) Endocrinological findings in sterile pink-eyed mice. J Reprod Fertil 42(1):51-8 |
| abstractText | Mice homozygous for rho-25h, a mutation at the pink-eye locus, are small, nervous and male sterile, with abnormal sperm morphology: females have very low fecundity. Evidence is presented that in both sexes the pars nervosa of the rho-25h/rho-25h pituitary contains degenerating nerve axons, that the hypothalamus has a reduced binding capacity for oestradiol-17 beta and that thyroid iodine binding is reduced. No changes were observed in the anterior pituitary. In rho-25h/rho-25h females, the uterus is threas-like and unresponsive to oestradiol, and the ovaries are small with many abnormal follicles. Possible modes of action of the rho locus are duscussed with reference to this and pre-existing data on the rho phenotype. |
