| First Author | Kaeser SA | Year | 2007 |
| Journal | Nat Genet | Volume | 39 |
| Issue | 12 | Pages | 1437-9 |
| PubMed ID | 18026102 | Mgi Jnum | J:130211 |
| Mgi Id | MGI:3771252 | Doi | 10.1038/ng.2007.23 |
| Citation | Kaeser SA, et al. (2007) Cystatin C modulates cerebral beta-amyloidosis. Nat Genet 39(12):1437-9 |
| abstractText | The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions. |
