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Allele : b2b2110Clo Mutant line 2110; Bench to Bassinet Program (B2B/CVDC), mutation 2110 Cecilia Lo
Primary Identifier  MGI:5498488 Allele Type  Chemically induced (ENU)
Gene  b2b2110Clo Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
Project Collection  B2B/CvDC
description  Summative Diagnosis:
Mutant Type 1: Cardiac phenotype (1 mutant): Double outlet right ventricle (DORV) with hypoplastic aortic arch
Mutant Type 2: Cardiac phenotype: Biventricular hypertrophy
Noncardiac phenotype: Anopthalmia/micropthalmia, craniofacial defects including agnathia, micrognathia and cleft palate

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0600 Double outlet right ventricle
2704 Aortic arch hypoplasia
4163 Micrognathia
4876 Cleft palate
7505 Biventricular hypertrophy

molecularNote  This ENU-induced mutation line was isolated in a screen at the University of Pittsburgh. More than one mutation in this line results in a discernible phenotype in a homozygous recessive screen. At least two segregating phenotype groups are identified. See b2b2110.1Clo and b2b2110.2Clo
  • mutations:
  • Undefined
  • synonyms:
  • Weasley,
  • Weasley
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Trail: Allele

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0 Mutation Involves

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Mouse alleles --> Mammalian phenotypes (MP terms)

 

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