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Allele : H2-Ab1<b-tm1Doi> histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Christophe Benoist and Diane Mathis
Primary Identifier  MGI:1927483 Allele Type  Targeted
Attribute String  Null/knockout Gene  H2-Ab1
Transmission  Germline Strain of Origin  129S2/SvPas
Is Recombinase  false Is Wild Type  false
molecularNote  The second exon was disrupted by the insertion of a neomycin resistance gene. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins.
  • mutations:
  • Insertion
  • synonyms:
  • A beta<0>,
  • A<b>beta<->,
  • MHC class II-,
  • H2-Ab1<tm1Doi>,
  • Class II<0>,
  • H2-Ab1<tm1Dim>,
  • AB0,
  • H2-Ab1<tm1Doi>,
  • H2-Ab1<tm1Dim>,
  • A<b>beta<->,
  • MHC-II-k.o.,
  • Class II<0>,
  • MHCII<->,
  • Abeta-,
  • MHCII<->,
  • H2-Ab1tm1Doi,
  • MHC class II-,
  • MHC-II-k.o.,
  • II<0>,
  • AB0,
  • Abeta-,
  • H2-Ab1tm1Doi,
  • II<0>,
  • A beta<0>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

27 Carried By

Trail: Allele

0 Driven By

177 Publication categories

Trail: Allele




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