| First Author | Maes B | Year | 2023 |
| Journal | J Exp Med | Volume | 220 |
| Issue | 9 | PubMed ID | 37347461 |
| Mgi Jnum | J:338082 | Mgi Id | MGI:7510052 |
| Doi | 10.1084/jem.20210788 | Citation | Maes B, et al. (2023) STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity. J Exp Med 220(9) |
| abstractText | Healthy adipose tissue (AT) contains ST2+ Tregs, ILC2s, and alternatively activated macrophages that are lost in mice or humans on high caloric diet. Understanding how this form of type 2 immunity is regulated could improve treatment of obesity. The STE20 kinase Thousand And One amino acid Kinase-3 (TAOK3) has been linked to obesity in mice and humans, but its precise function is unknown. We found that ST2+ Tregs are upregulated in visceral epididymal white AT (eWAT) of Taok3-/- mice, dependent on IL-33 and the kinase activity of TAOK3. Upon high fat diet feeding, metabolic dysfunction was attenuated in Taok3-/- mice. ST2+ Tregs disappeared from eWAT in obese wild-type mice, but this was not the case in Taok3-/- mice. Mechanistically, AT Taok3-/- Tregs were intrinsically more responsive to IL-33, through higher expression of ST2, and expressed more PPARgamma and type 2 cytokines. Thus, TAOK3 inhibits adipose tissue Tregs and regulates immunometabolism under excessive caloric intake. |
