| First Author | Yan W | Year | 2019 |
| Journal | Eur J Med Res | Volume | 24 |
| Issue | 1 | Pages | 26 |
| PubMed ID | 31351483 | Mgi Jnum | J:290603 |
| Mgi Id | MGI:6442718 | Doi | 10.1186/s40001-019-0384-7 |
| Citation | Yan W, et al. (2019) Dok-3 deficient mice display different immune clustering and Tim-3 expression. Eur J Med Res 24(1):26 |
| abstractText | BACKGROUND: Dok-3 has been shown to play an important role in immune system. Tim-3 also has been recognized as an important immune regulator which involves in many diseases. The relationship of them is still unclear. METHODS: We detected the expression of Tim-3 on spleen immune cells from Dok-3 deficient mice and control mice by flow cytometry. RESULTS: In this article, we found that Dok-3(-/-) mice display almost entirely different immune clustering characteristics compared with wild type 129 mice. The CD4 T cells and CD8 T cells decreased and DC cells, macrophages, MDSCs increased when the Dok-3 gene knocked-out. The Tim-3 expression on CD4 T cells, CD8 T cells, NK cells, DC cells increased when the Dok-3 gene knocked-out. The macrophages and MDSCs just display the opposite results. CONCLUSIONS: Although Dok-3(-/-) mice display different immune clustering and Tim-3 expression, the mechanism still needs further study. |
