| Primary Identifier | MGI:5751186 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | C9orf72 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The locus is targeted by two zinc finger nucleases (ZFNs) at the TGTTGC sequence located immediately downstream of the exon 2 ATG (GRCm38:4:35,218,827) resulting in a 79 bp deletion in exon 2 (38 bp upstream of the start codon and 38 bp downstream), which maps to mm10/GRCm38:4:35,218,896-35,218,822. Western blot of brain lysates shows homozygous null mice have complete loss of full-length protein, however, mRNA expression levels from the mutant allele are similar to wild type. |
