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Allele : Bmx<tm1.1Npa> BMX non-receptor tyrosine kinase; targeted mutation 1.1, Novartis Pharma AG

Primary Identifier  MGI:5013470 Allele Type  Targeted
Gene  Bmx Transmission  Germline
Strain of Origin  BALB/c Is Recombinase  false
Is Wild Type  false
molecularNote  Nucleotides substitutions in exon 14 result in the amino acid substitution of arginine for lysine at position 421 (K421R). This mutation responds to the human mutation K445R that results in the loss of kinase activity. A floxed neo cassette was removed by cre-mediated recombination.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • BMX<tm1(K421R)Npa>,
  • BMX<tm1(K421R)Npa>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

5 Publication categories

Trail: Allele