| First Author | Ding X | Year | 2012 |
| Journal | Cell Metab | Volume | 16 |
| Issue | 3 | Pages | 387-93 |
| PubMed ID | 22958921 | Mgi Jnum | J:189018 |
| Mgi Id | MGI:5444068 | Doi | 10.1016/j.cmet.2012.08.002 |
| Citation | Ding X, et al. (2012) betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab 16(3):387-93 |
| abstractText | Fibroblast growth factor 21 (FGF21) is a fasting-induced hepatokine that has potent pharmacologic effects in mice, which include improving insulin sensitivity and blunting growth. The single-transmembrane protein betaKlotho functions as a coreceptor for FGF21 in vitro. To determine if betaKlotho is required for FGF21 action in vivo, we generated whole-body and adipose tissue-selective betaKlotho-knockout mice. All of the effects of FGF21 on growth and metabolism were lost in whole-body betaKlotho-knockout mice. Selective elimination of betaKlotho in adipose tissue blocked the acute insulin-sensitizing effects of FGF21. Taken together, these data demonstrate that betaKlotho is essential for FGF21 activity and that betaKlotho in adipose tissue contributes to the beneficial metabolic actions of FGF21. |
