| First Author | Sturmlechner I | Year | 2021 |
| Journal | Science | Volume | 374 |
| Issue | 6567 | Pages | eabb3420 |
| PubMed ID | 34709885 | Mgi Jnum | J:313419 |
| Mgi Id | MGI:6784107 | Doi | 10.1126/science.abb3420 |
| Citation | Sturmlechner I, et al. (2021) p21 produces a bioactive secretome that places stressed cells under immunosurveillance. Science 374(6567):eabb3420 |
| abstractText | Immune cells identify and destroy damaged cells to prevent them from causing cancer or other pathologies by mechanisms that remain poorly understood. Here, we report that the cell-cycle inhibitor p21 places cells under immunosurveillance to establish a biological timer mechanism that controls cell fate. p21 activates retinoblastoma protein (Rb)âdependent transcription at select gene promoters to generate a complex bioactive secretome, termed p21-activated secretory phenotype (PASP). The PASP includes the chemokine CXCL14, which promptly attracts macrophages. These macrophages disengage if cells normalize p21 within 4 days, but if p21 induction persists, they polarize toward an M1 phenotype and lymphocytes mount a cytotoxic T cell response to eliminate target cells, including preneoplastic cells. Thus, p21 concurrently induces proliferative arrest and immunosurveillance of cells under duress. |
