| First Author | Betourne A | Year | 2009 |
| Journal | Neuropharmacology | Volume | 56 |
| Issue | 3 | Pages | 615-25 |
| PubMed ID | 19059420 | Mgi Jnum | J:179502 |
| Mgi Id | MGI:5302496 | Doi | 10.1016/j.neuropharm.2008.11.001 |
| Citation | Betourne A, et al. (2009) Involvement of hippocampal CA3 K(ATP) channels in contextual memory. Neuropharmacology 56(3):615-25 |
| abstractText | This paper evaluates the involvement of hippocampal ATP-sensitive potassium channels (K(ATP)) in learning and memory. After confirming expression of the Kir6.2 subunit in the CA3 region of C57BL/6J mice, we performed intra-hippocampal pharmacological injections of specific openers and blockers of K(ATP) channels. The opener diazoxide, the blocker tolbutamide, or a mixture of both, were bilaterally injected in the CA3 region before we subjected the animals to a fear conditioning paradigm. Diazoxide strongly impaired contextual memory of mice at both doses tested. This impairment was specifically reversed by co-injecting the blocker tolbutamide. Moreover, we studied the mnemonic abilities of mice deleted for the Kir6.2 subunit. These mice were backcrossed to C57BL/6J mice and tested in two learning paradigms. We found a significant impairment of contextual and tone memories in the Kir6.2 knock-out mice when compared with heterozygous or wild-type animals. Furthermore, these animals were also slightly impaired in a spatial version of the Morris water maze task. Our data suggest a specific involvement of hippocampal K(ATP) Kir6.2/SUR1 channels in memory processes. |
