Primary Identifier | MGI:3783350 | Allele Type | Targeted |
Attribute String | Modified isoform(s) | Gene | Ace |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The neomycin resistance gene cassette followed by cardiac specific alpha-myosin heavy chain promoter was inserted between the endogenous somatic promoter and exon 1. ACE activity and protein expression was markedly increased in heart but virtually undetectable in kidney of homozygous mutant mice. |