Primary Identifier | MGI:3056530 | Allele Type | Targeted |
Gene | Lats2 | Transmission | Germline |
Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Serine 371 was replaced with an in-frame stop codon followed by an inverted neomycin cassette via homologous recombination, disrupting translation of the carboxy-terminal kinase domain. Western and Northern analysis confirms absence of full-length or a shorter Lats2 peptide and presence of a longer mRNA. |