| First Author | Yu Q | Year | 2006 |
| Journal | Cancer Cell | Volume | 9 |
| Issue | 1 | Pages | 23-32 |
| PubMed ID | 16413469 | Mgi Jnum | J:105043 |
| Mgi Id | MGI:3613334 | Doi | 10.1016/j.ccr.2005.12.012 |
| Citation | Yu Q, et al. (2006) Requirement for CDK4 kinase function in breast cancer. Cancer Cell 9(1):23-32 |
| abstractText | Cyclin D1 is overexpressed in the majority of human breast cancers. We previously found that mice lacking cyclin D1 are resistant to mammary carcinomas triggered by the ErbB-2 oncogene. In this study, we investigated which function of cyclin D1 is required for ErbB-2-driven mammary oncogenesis. We report that the ability of cyclin D1 to activate cyclin-dependent kinase CDK4 underlies the critical role for cyclin D1 in breast cancer formation. We also found that the continued presence of CDK4-associated kinase activity is required to maintain breast tumorigenesis. We analyzed primary human breast cancers and found high cyclin D1 levels in a subset (approximately 25%) of ErbB-2-overexpressing tumors. We propose that this subset of breast cancer patients might benefit from inhibiting CDK4 kinase. |
