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Publication : Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice.

First Author  Armstrong JF Year  1998
Journal  Br J Cancer Volume  78
Issue  4 Pages  484-5
PubMed ID  9716031 Mgi Jnum  J:49159
Mgi Id  MGI:1276789 Doi  10.1038/bjc.1998.519
Citation  Armstrong JF, et al. (1998) Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice. Br J Cancer 78(4):484-5
abstractText  The previously reported earlier onset of pituitary tumours in cross-bred mice inheriting a mutant Rb-1 allele paternally has been ascribed to imprinting of an Rb-1- linked gene. Here, we demonstrate that, as predicted from this mechanism, there is no effect of the parent of origin of the mutation in inbred mice.
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