| Primary Identifier | MGI:2388611 | Allele Type | Targeted |
| Gene | Esr1 | Transmission | Germline |
| Strain of Origin | 129P2/OlaHsd-Hprt1<b-m3> | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Missense mutations at codons 207 and 208 were introduced at the endogenous locus via homologous recombination. The mutations were designed to substitute a glutamate (207) and glycine (208) with alanine residues. A floxed neo cassette was integrated upstream in intron 2 for selection. Mice carrying this allele were used to generate Esr1tm1.1Lja. |
