| First Author | Ke Y | Year | 2007 |
| Journal | Oncogene | Volume | 26 |
| Issue | 34 | Pages | 4951-60 |
| PubMed ID | 17310989 | Mgi Jnum | J:125541 |
| Mgi Id | MGI:3759020 | Doi | 10.1038/sj.onc.1210315 |
| Citation | Ke Y, et al. (2007) Role of Gab2 in mammary tumorigenesis and metastasis. Oncogene 26(34):4951-60 |
| abstractText | Overexpression of the adaptor/scaffolding protein Gab2 has been detected in primary human breast cancer cells and cell lines, although its functional significance in breast carcinogenesis is not fully understood. Here, we show a requirement for Gab2 in promoting mammary tumor metastasis. Although Gab2 expression levels were elevated in mammary tumors induced by the Neu (ErbB-2) oncogene, homozygous deletion of Gab2 in mice had only a modest effect on the initiation of Neu-induced mammary tumors. Notably, ablation of Gab2 severely suppressed lung metastasis. Gab2-deficient cancer cells displayed normal Akt activities, and their proliferative rate in vitro was similar to control cells. However, Gab2(-/-) cancer cells exhibited decreased migration and impaired Erk activation, and the defects were rescued by re-introduction of Gab2 into Gab2(-/-) cells. These findings suggest that although Gab2 overexpression may confer growth advantage to tumor cells, the functional requirement for Gab2 in mammary tumor initiation/growth may be dispensable, and that Gab2 may have a prominent role in promoting mammary tumor metastasis. |
