Primary Identifier | MGI:5308446 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Slco1c1 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 3 was flanked with loxP sites. Deletion of exon 3 by cre excision caused loss of function by removing part of the organic anion transporter domain and generating a frameshift from exon 2 to exon 4-11 followed by a premature stop at codon 52. PCR analysis confirmed the removal of exon 3 in mRNA. |