| First Author | Kleindienst P | Year | 2000 |
| Journal | Blood | Volume | 95 |
| Issue | 8 | Pages | 2610-6 |
| PubMed ID | 10753841 | Mgi Jnum | J:132925 |
| Mgi Id | MGI:3777202 | Doi | 10.1182/blood.v95.8.2610 |
| Citation | Kleindienst P, et al. (2000) Functional comparison of thymic B cells and dendritic cells in vivo. Blood 95(8):2610-6 |
| abstractText | In this report we present a transgenic mouse model in which we targeted gene expression specifically to B-lymphocytes. Using the human CD19 promoter, we expressed major histocompatibility complex class II I-E molecules specifically on B cells of all tissues, but not on other cell types. If only B cells expressed I-E in a class II-deficient background, positive selection of CD4(+) T cells could not be observed. A comparison of the frequencies of I-E reactive Vbeta5(+) and Vbeta11(+) T cells shows that I-E expression on thymic B cells is sufficient to negatively select I-E reactive CD4(+) T cells partially, but not CD8(+) T cells. Thus partial negative but no positive selection events can be induced by B-lymphocytes in vivo. (Blood. 2000;95:2610-2616) |
