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Allele : Cdkn2a<tm1Rdp> cyclin dependent kinase inhibitor 2A; targeted mutation 1, Ronald DePinho
Primary Identifier  MGI:1857942 Allele Type  Targeted
Attribute String  Null/knockout Gene  Cdkn2a
Transmission  Germline Strain of Origin  STOCK 129/Sv and C57BL/6J and SJL
Is Recombinase  false Is Wild Type  false
description  Phenotypic Similarity to Human Syndrome in Orthologous Human Gene: human supratentorial ependymoma subgroup in homozygous mice (J:163931)
molecularNote  Exons E2 and E3 were deleted and replaced by a neomycin cassette. Note that both the p16Ink4a and p19ARF alternative splice transcripts are mutated in this allele.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • INK4a-Arf<->,
  • Inkdelta2/3 null,
  • Cdkn2a-,
  • p16<INK4a>,
  • ARF-,
  • ARF-,
  • Cdkn2a<lox>,
  • p16<INK4a->,
  • p16-KO,
  • Ink4a-Arf-null,
  • Inkdelta2/3 null,
  • Cdkn2a<lox>,
  • Ink4a/Arf-,
  • Ink4a/Arf<KO>,
  • INK4a-,
  • Ink4a-Arf-null,
  • INK4a-,
  • Cdkn2a-,
  • Ink4a/Arf-,
  • Ink4a/arf-,
  • p16<INK4a>,
  • INK4a-Arf<->,
  • p16-KO,
  • p16p19<null>,
  • ink4a-,
  • p16p19<null>,
  • Ink4a/arf-,
  • ink4a-,
  • p16<INK4a->,
  • Ink4a/Arf<KO>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

9 Carried By

Trail: Allele

0 Driven By

329 Publication categories

Trail: Allele




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