| First Author | Gribaudo S | Year | 2021 |
| Journal | Int J Mol Sci | Volume | 22 |
| Issue | 8 | PubMed ID | 33924098 |
| Mgi Jnum | J:308993 | Mgi Id | MGI:6753437 |
| Doi | 10.3390/ijms22084269 | Citation | Gribaudo S, et al. (2021) Neurogranin Regulates Adult-Born Olfactory Granule Cell Spine Density and Odor-Reward Associative Memory in Mice. Int J Mol Sci 22(8) |
| abstractText | Neurogranin (Ng) is a brain-specific postsynaptic protein, whose role in modulating Ca(2+)/calmodulin signaling in glutamatergic neurons has been linked to enhancement in synaptic plasticity and cognitive functions. Accordingly, Ng knock-out (Ng-ko) mice display hippocampal-dependent learning and memory impairments associated with a deficit in long-term potentiation induction. In the adult olfactory bulb (OB), Ng is expressed by a large population of GABAergic granule cells (GCs) that are continuously generated during adult life, undergo high synaptic remodeling in response to the sensory context, and play a key role in odor processing. However, the possible implication of Ng in OB plasticity and function is yet to be investigated. Here, we show that Ng expression in the OB is associated with the mature state of adult-born GCs, where its active-phosphorylated form is concentrated at post-synaptic sites. Constitutive loss of Ng in Ng-ko mice resulted in defective spine density in adult-born GCs, while their survival remained unaltered. Moreover, Ng-ko mice show an impaired odor-reward associative memory coupled with reduced expression of the activity-dependent transcription factor Zif268 in olfactory GCs. Overall, our data support a role for Ng in the molecular mechanisms underlying GC plasticity and the formation of olfactory associative memory. |
