| First Author | Ransohoff RM | Year | 2006 |
| Journal | J Clin Invest | Volume | 116 |
| Issue | 9 | Pages | 2313-6 |
| PubMed ID | 16955130 | Mgi Jnum | J:114520 |
| Mgi Id | MGI:3689263 | Doi | 10.1172/JCI29834 |
| Citation | Ransohoff RM (2006) A mighty mouse: building a better model of multiple sclerosis. J Clin Invest 116(9):2313-6 |
| abstractText | The 2 cardinal cell populations mediating adaptive immunity are T and B lymphocytes. These cells play important but poorly understood roles in the immunopathological demyelinating disease multiple sclerosis (MS) and in a widely used animal model of human MS known as EAE. In the current issue of the JCI, 2 research teams report their parallel studies of double-transgenic mice expressing T and B cell receptors that recognize the same myelin protein (see the related articles beginning on pages 2385 and 2393). More than half of the double-transgenic mice spontaneously developed autoimmune demyelination in their spinal cords and optic nerves, exhibiting pathologies reminiscent of human MS. The studies describe an important new model for MS research. |
