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Publication : Effect of biotin depletion on spike-wave seizures in the tottering mutant mouse.

First Author  Krause KH Year  1997
Journal  Int J Vitam Nutr Res Volume  67
Issue  6 Pages  461-3
PubMed ID  9433681 Mgi Jnum  J:45255
Mgi Id  MGI:1194701 Citation  Krause KH, et al. (1997) Effect of biotin depletion on spike-wave seizures in the tottering mutant mouse. Int J Vitam Nutr Res 67(6):461-3
abstractText  Influence of depletion of biotin on spontaneously occurring spike-wave seizures in the tottering mutant mouse was tested by electrocorticographic recordings over three hours in five mice fed a biotin deficient diet. Frequency of seizures as well as percent of time with epileptic discharges were clearly lowered in the biotin deficient animals compared with eight mice of the same age under normal food (p < 0.01 in Wilcoxon's U-test).
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