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Allele : Mdm4<tm1.1Chj> transformed mouse 3T3 cell double minute 4; targeted mutation 1.1, Jiandong Chen
Primary Identifier  MGI:6156967 Allele Type  Targeted
Attribute String  Hypomorph Gene  Mdm4
Transmission  Germline Strain of Origin  129S6/SvEvTac and C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  A floxed neo cassette was inserted in intron 7 and W201S/W202G mutations were inserted in exon 8 via homologous recombination. Cre mediated recombination removed the neo cassette. This mutation disrupts intramolecular interactions and binding to CSNK1A1 and acidic domain-TRP53 core binding.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • MDMX<SG>,
  • MDMX<SG>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories





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