| First Author | Zhang X | Year | 2011 |
| Journal | Mol Cell | Volume | 41 |
| Issue | 4 | Pages | 371-83 |
| PubMed ID | 21329876 | Mgi Jnum | J:170852 |
| Mgi Id | MGI:4947481 | Doi | 10.1016/j.molcel.2011.01.020 |
| Citation | Zhang X, et al. (2011) The ATM kinase induces microRNA biogenesis in the DNA damage response. Mol Cell 41(4):371-83 |
| abstractText | The DNA damage response involves a complex network of processes that detect and repair DNA damage. Here we show that miRNA biogenesis is globally induced upon DNA damage in an ATM-dependent manner. About one-fourth of miRNAs are significantly upregulated after DNA damage, while loss of ATM abolishes their induction. KH-type splicing regulatory protein (KSRP) is a key player that translates DNA damage signaling to miRNA biogenesis. The ATM kinase directly binds to and phosphorylates KSRP, leading to enhanced interaction between KSRP and pri-miRNAs and increased KSRP activity in miRNA processing. Mutations of the ATM phosphorylation sites of KSRP impaired its activity in regulating miRNAs. These findings reveal a mechanism by which DNA damage signaling is linked to miRNA biogenesis. |
