| First Author | Lo TH | Year | 2014 |
| Journal | Kidney Int | Volume | 86 |
| Issue | 6 | Pages | 1174-86 |
| PubMed ID | 24918157 | Mgi Jnum | J:292387 |
| Mgi Id | MGI:6449959 | Doi | 10.1038/ki.2014.205 |
| Citation | Lo TH, et al. (2014) TREM-1 regulates macrophage polarization in ureteral obstruction. Kidney Int 86(6):1174-86 |
| abstractText | Chronic kidney disease (CKD) is an emerging worldwide public health problem. Inflammatory cell infiltration and activation during the early stages in injured kidneys is a common pathologic feature of CKD. Here, we determined whether an important inflammatory regulator, triggering receptor expressed on myeloid cells (TREM)-1, is upregulated in renal tissues collected from mouse ureteral obstruction-induced nephritis. TREM-1 is crucial for modulating macrophage polarization, and has a pivotal role in mediating tubular injury and interstitial collagen deposition in obstructive nephritis. Lysates from nephritic kidneys triggered a TREM-1-dependent M1 polarization ex vivo, consistent with the observation that granulocyte-macrophage colony-stimulating factor (GM-CSF)-derived M1 macrophages express higher levels of TREM-1 in comparison with M-CSF-derived cells. Moreover, agonistic TREM-1 cross-link significantly strengthens the inductions of iNOS and GM-CSF in M1 cells. These observations are validated by a strong clinical correlation between infiltrating TREM-1-expressing/iNOS-positive macrophages and renal injury in human obstructive nephropathy. Thus, TREM-1 may be a potential diagnostic and therapeutic target in human kidney disease. |
