| First Author | Yan D | Year | 2013 |
| Journal | Neuron | Volume | 78 |
| Issue | 4 | Pages | 687-99 |
| PubMed ID | 23719165 | Mgi Jnum | J:201543 |
| Mgi Id | MGI:5514311 | Doi | 10.1016/j.neuron.2013.02.031 |
| Citation | Yan D, et al. (2013) Homeostatic control of synaptic transmission by distinct glutamate receptors. Neuron 78(4):687-99 |
| abstractText | Glutamate is the most abundant excitatory neurotransmitter in the brain, and distinct classes of glutamate receptors coordinate synaptic transmission and spike generation upon various levels of neuronal activity. However, the mechanisms remain unclear. Here, we found that loss of synaptic AMPA receptors increased kainate receptor activity in cerebellar granule cells without changing NMDA receptors. The augmentation of kainate receptor-mediated currents in the absence of AMPA receptor activity is required for spike generation and is mediated by the increased expression of the GluK5 high-affinity kainate receptor subunit. Increase in GluK5 expression is sufficient to enhance kainate receptor activity by modulating receptor channel properties, but not localization. Furthermore, we demonstrate that the combined loss of the AMPA receptor auxiliary TARPgamma-2 subunit and the GluK5 subunit leads to early mouse lethality. Our findings reveal mechanisms mediated by distinct classes of postsynaptic glutamate receptors for the homeostatic maintenance of the neuronal activity. |
