First Author | Rampias T | Year | 2014 |
Journal | Nat Med | Volume | 20 |
Issue | 10 | Pages | 1199-205 |
PubMed ID | 25194568 | Mgi Jnum | J:227748 |
Mgi Id | MGI:5702555 | Doi | 10.1038/nm.3678 |
Citation | Rampias T, et al. (2014) A new tumor suppressor role for the Notch pathway in bladder cancer. Nat Med 20(10):1199-205 |
abstractText | The Notch signaling pathway controls cell fates through interactions between neighboring cells by positively or negatively affecting the processes of proliferation, differentiation and apoptosis in a context-dependent manner. This pathway has been implicated in human cancer as both an oncogene and a tumor suppressor. Here we report new inactivating mutations in Notch pathway components in over 40% of human bladder cancers examined. Bladder cancer is the fourth most commonly diagnosed malignancy in the male population of the United States. Thus far, driver mutations in fibroblast growth factor receptor 3 (FGFR3) and, less commonly, in RAS proteins have been identified. We show that Notch activation in bladder cancer cells suppresses proliferation both in vitro and in vivo by directly upregulating dual-specificity phosphatases (DUSPs), thus reducing the phosphorylation of ERK1 and ERK2 (ERK1/2). In mouse models, genetic inactivation of Notch signaling leads to Erk1/2 phosphorylation, resulting in tumorigenesis in the urinary tract. Collectively our findings show that loss of Notch activity is a driving event in urothelial cancer. |